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タイトル: Effects of a Single Bolus Intravenous Dose of Tramadol on Minimum Alveolar Concentration (MAC) of Sevoflurane in Dogs
著者: ITAMI, Takaharu
KAWASE, Kodai
TAMARU, Naomichi
ISHIZUKA, Tomohito
TAMURA, Jun
MIYOSHI, Kenjirou
UMAR, Mohammed A.
INOUE, Hiroki
YAMASHITA, Kazuto
キーワード: canine
minimum alveolar concentration (MAC)
O-desmethyltramadol (M1)
sevoflurane
tramadol
発行日: May-2013
出版者: 日本獣医学会
抄録: Tramadol is an atypical opioid analgesic widely used in small animal practice. This study was designed to determine the effect of a single intravenous (IV) dose of tramadol on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Six beagle dogs were anesthetized twice to determine the sevoflurane MAC with or without an administration of tramadol (4mg/kg, IV) at 7 days interval. The sevoflurane MAC was determined using a tail clamp method in each dog ventilated with positive pressure ventilation. The tramadol administration produced a significant reduction in the sevoflurane MAC by 22.3±12.2% (1.44±0.28% with tramadol versus 1.86±0.30% without tramadol, P=0.010). This MAC reduction had been determined from 122±19 to 180±41 min following the tramadol administration. During this period, the plasma concentrations of tramadol and its metabolite, O-desmethyltramadol (M1), decreased from 429±64 to 332±55 ng/ml and from 136±24 to 114±68 ng/ml, respectively, but these changes were not statistically significant. There was no significant difference in heart rate, mean arterial blood pressure and SpO_2 between the control and tramadol treatment. The dogs that received tramadol treatment sometimes breathed spontaneously. Therefore, their respiratory rates significantly increased, and PETCO_2 decreased during the MAC determination. In conclusion, the single IV dose of tramadol produced a significant reduction in the sevoflurane MAC in dogs.
URI: http://hdl.handle.net/10659/3812
著作権等: ©2013 The Japanese Society of Veterinary Science
出現コレクション:学術論文(雑誌)

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