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タイトル: Connexin 43-dependent tumor-suppressing effect of the Bowman-Birk protease inhibitor on M5076 ovarian sarcoma-bearing mice
著者: Sakurai, Noritaka
Suzuki, Kazuyuki
Sano, Yuki
Saito, Teruyoshi
Yoshimura, Hisashi
Nishimura, Yukie
Yano, Tomohiro
Sadzuka, Yasuyuki
Asano, Ryuji
発行日: Sep-2008
出版者: Spandidos Publications
抄録: The present study was designed to confirm whether the Bowman-Birk inhibitor (BBI) induces an increase in p27 accumulation without S phase kinase-associated protein 2 (skp2) degradation by means of the expression of connexin (Cx) 43 as a gap junctional intercellular communication (GJIC)-dependent pathway in mice with M5076 ovarian sarcoma. M5076 ovarian sarcomas (1x10^5 cells/animal) were subcutaneously transplanted onto the backs of BDF_1 mice receiving 10, 20 or 40 mg/kg of purified BBI intraperitoneally. Relative tumor weight (p<0.01, r=0.503) was negatively correlated with the dose of BBI. In contrast, the relative density of Cx43 mRNA (p<0.01, r=0.570) and Cx43 (p<0.01, r=0.718) was positively correlated with the dose of BBI, as were p21 (p<0.01, r=0.633), p27 (p<0.01, r=0.561) and skp2 (p<0.01, r=0.733). We therefore suggest that the anti-carcinogenic effects of BBI induce negative growth control by means of an increase in p27 accumulation caused by the expression of Cx43 as a GJIC pathway.
URI: http://hdl.handle.net/10659/1785
ISSN: 1791-2997
出現コレクション:学術論文(雑誌)

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